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想求沈药的期末考试题,想要问问有没有各科历年的期末试卷啊

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for_you 发表于 11-7-24 13:02:38 | 只看该作者 回帖奖励 |倒序浏览 |阅读模式
本人12年考研,想要问问有没有各科历年的期末试卷啊
沙发
beyond 发表于 11-7-30 20:25:56 | 只看该作者
沈阳药科大学试卷
药剂学 I 试卷(A 卷,2007 年 7 月)
适用对象:2003 级药学(英语)专业 专业 题 满 得 号 分 分 一 10 二 20 三 10 级 四 10 班 五 10 姓名 六 10 七 12 学号 八 18 总 分 100
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一,名词解释(每题 1 分,共计 10 分) 1. Consolvency: The solubility of weak electrolytes and nonpolar molecules can be increased by the addition of water-misible solvents. This process is known as Consolvency. 2. Tincture: are alcoholic or hydroalcoholic solutions prepared from vegetable materials or from chemical substances. 3. Flocculation: particles experience attraction at significant interparticle distance and form the fluffy aggregates. 4. Isotonic solution: solutions that have the same osmotic pressure as the body fluid. 5. Critical relative humidity: is defined as the relative humidity of the surrounding atmosphere at which the material begins to absorb moisture from the moisture, below which it will not absorb atmospheric moisture. 6. Displacement value: weight ratio of the drug substance and the base having the same volume as the drug substance. 7. Extracts (浸膏剂): traditional Chinese medicine is extracted with solvents, and the solvent is completely evaporated, getting the semisolid state or powder state substance is called extracts. 8. Pyrogen: are products of metabolism of microorganisms, endotoxins the most prevalent
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沈阳药科大学试卷
9. Sedimentation volume: is expressed by the ratio of the equivalent volume of the sediment to the total volume of the suspension. The higher, the better stability. 10. Wet gum method: also referred to as the 4:2:1 method, used to prepare emulsion. Every 4 parts by volume of oil, 2 parts of water and 1 part of gum are added in preparing the initial emulsion. Mucilage of the gum is prepared by triturating the emulsifier with water, the oil is then added slowly in portion, and the mixture is triturated to emulsify the oil. 二,填空(每空 0.5 分,共计 20 分) 1. If two surfactants with HLB values 9.0 and 12.0 respectively are blended in a 2:1 ratio, then the HLB value of the system will be (10 ). 2. Emulsion is mainly composed of (oil phase ) (aqueous phase ) and ( emulsifier ). 3. Pyrogens have the following properties, (thermostable), (filterable), (water soluble ) and (non-volatile). 4. ( Lecithin ) and ( Poloxamer 188 ) can be used emulsifiers for fat emulsions for intravenous injection. 5. When a small amount of a potent substance is to be mixed with a large amount of diluent, we should use (geometric) method. 6. Aerosol is composed of the following four parts, (product concentrate), (propellant), (valve assembly) and (Pressurized package). 7. Empty capsules are manufactured in eight various sizes, they are (000,00,0,1,2,3,4,5 ). 8. Sugar coating includes the following process, (waterproofing and sealing) if needed, (subcoating), (smooth and final rounding), (finishing and coloring) if desired and (polishing ). 9. Pyrogens can be tested with (Rabbit test) and (limulus amoebocyte lysate) method. 10. Write down the full name of the following abbreviation HPMC(Hydropropelmethylcelluclose) MC(methylcelluclose ) GMP (Good manufacture practice )
CMC-Na(Sodium carboxymethylcelluclose ) CAP (celluclose acetate phthalate )
CMS-Na(carboxymethyl starch sodium)
11. Describe the function of the following excipients in Pharmaceutics Glycero-gelatin base (base of suppository )
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沈阳药科大学试卷
Carbopol (base for gels, suspending agent) PVP ( binders, pore-forming agent, suspending agent, viscometer glycerin (solvent, wetting agent, cosolvent ) PEG (solvent, bases for ointment ) ) and suppository, water-soluble ) ) lubricant,pore-forming agent, plasticizer ) Chlorobutanol ( antibacterials MCC ( fillers, binder, disintegrant PVA (film-forming material ) Corn oil (solvent )
HPMC ( binder, suspending agent
Sodium chloride (osmotic pressure adjustment ) 三,判断题(每题 1 分,共计 10 分) 1. Antibacterials should be added into multi-dosing injections and intravenous injections. ( × ). 2. Normal serum osmolarity values are in the vicinity of 298 mOsm. ( √ ophthalmic preparations. (√ ) 4. For the general tablet, it should disintegrate in 15 min, for film coated tablet, it should disintegrate in 30 min. (× ) 5. For the pH adjustment of injection, it is a combination of compatibility, chemical stability and solubility. (√ ) 6. After mixing two water soluble drugs, their critical relative humidity will be the sum of their individual critical relative humidity. ( × ). 7. Suppository and ointment belong to semisolid preparation. ( × ) 8. Hard gelatin capsules are suitable for hygroscopic drugs. (× ) 9. By changing the dosage form, the pharmacological response can be changed. (√ ). 10. Suspension can be used for drugs with sharp therapeutic window. ( 四,单项选择题(共计 10 分) 1. The first Chinese Pharmacopoeia was issued in ( D A. 1949 B. 1950 C. 1952 D. 1953 ) C.Dispersing system 2. Dosage form can't be classified according to ( B A.Administration route B.Formulation
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)
3. Phosphate buffer and boric acid buffer are commonly used to prepare
×
)
) E. 1957
沈阳药科大学试卷
D.Preparation method 3.The function of tragacanth(西黄蓍胶) in suspension is ( A ) A. Suspending agent agent B. Diluent C. Wetting agent D. Flocculating E. deflocculating agent
4.According to Chinese Pharmacopoeia, water for injection should be(D ) A.pure water D.Redistilled water B.distilled water E.Ultrapure water C.deionized water
5. pH of injection should be in the range of ( B) A.4~11 B.4~9 C.2~9 D.3~8 E.5~8
6. In the quality requirement of ophthalmic drops, which one is different from that of injection ( D ) A. pH B. Osmotic pressure C. Sterility D. Pyrogen E. clarity
7.Which of the following tablet can bypass the hepatic metabolism (C ) A.Effervescent tablet D.Solution tablet B.Dispersing tablet E.Chewable tablet C.Sublingual tablet
8.In vitro parameter reflecting the in vivo absorption of water-insoluble drugs is (B) A.Disintegration time D.Weight variation B.Dissolution rate E.Hardness ) C.Friability
9.Which of the following belongs to two-phase aerosol( A A. Solution aerosol B. O/W emulsion
aerosol C. W/O emulsion aerosol
D.Suspending aerosol
E.W/O/ W emulsion aerosol
10.The biggest difference between general ointment and ophthalmic ointment is ( A ) A. Type of base B. Sterility C. Preparation method D. Appearance
五,多选题(每题两分,共计 10 分) 1.Which of the following belongs to water-soluble bases of ointment: B D ) ( A.Stearly alcohol B.PEG C. Starch
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D.CMC-Na
沈阳药科大学试卷
2.Which of the following excipients can be used for direct compression(BCDE ) A.EC B.Spray dried lactose C.MCC
D.Modified starch
E.Dicalcium phosphate
3.Which of the following can be used as binders of tablets (CD ) A. starch Dry B. Talc C. Syrup D. Starch mucilage E. Aerosol
4. Physicochemical properties measurement of sterile powder injections include (BDE ) A.Thermal stability D.Powder crystalline B.CRH C.Rheology E.Bulk density of the powder )
5.Sources of pyrogen contamination include( ABCDE A.Solvent
B.Medicament C. Containers and equipment E.Infusion device
D.In the preparation process
六,计算题(共计 10 分) 1. To prepare 100 ml 2% Morphine hydrochloride solution, how much sodium chloride is required to make the solution isotonic ( for Morphine hydrochloride, the freezing point of 1% solution 0.086; b=0.58 for NaCl). ( 5 分) w=(0.52-2*0.086)/0.58=0.6g
2.The weight of a blank base suppository is 3.0g,the weight of suppository containing 70% active drug is 5.3g. Now we need to preparing suppositories containing 500 mg active drug in each suppository, please write out the formulation for 1000 suppository.
DV=5.3×70%/(3.0-5.3×30%)=2.63 drug:500×1000=500g base: (3.0-0.5/2.63)×1000=2809.89 g
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沈阳药科大学试卷
七,处方题(共计 12 分) Analyze the following preparation, indicating which dosage form it belongs to and the function of each ingredient in the formation. In addition, describe the preparation process. 1.Vitamin C EDTA NaHCO3 NaHSO3 Water for injection to make 104 0.05 49 2 g g g g active drug substance chelator pH adjuster antioxidant solvent
1000 ml
EDTA Vc NaHSO3 dissolved in water + add NaHCO3 slowly
adjust the pH to the accurate volume solution filtered transferred to the final container and sealed sterilization Quality control
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沈阳药科大学试卷
2. Loratadine(氯雷他定) Corn starch Lactose 10% starch mucilage L-HPC Talc Magnesium stearate Preparation process:
1g 30 g 25 g q.s. 3g 2g 0.5g filler filler binder disintegrant glidant lubricant
Loratadine + corn starch + lactose homogeneously mixed add 10% starch mucilage preparing damp mass screening the damp mass into granules drying the granules sizing the granules by dry screening Adding L-HPC, Talc and magnesium stearate and blending by compression. forming tablets
八,简答题(共计 18 分) 1. Describe factors influencing drug absorption from rectal suppositories. (4 分) Physicological factors: Colonic content Circulation route: 2cm pH and lack of buffering capacity of the rectal fluids Physicochemcial factors of the drug and suppository base Lipid-water solubility Particle size Nature of the base
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沈阳药科大学试卷
2. Which liquid contents can't be filled in soft gelatin capsules.( 4 分) Water cannot exceed 5% pH must be between 2.5 and 7.5 low molecular weight water soluble and volatile compounds must be excluded aldehydes must be excluded strong acids, strong based, salts of strong acid or bases may hydrolyze gelatin Emulsions Contents must flow under gravity at <35 degrees
3. Describe the advantages of tablet film coating ( In English) ( 5 分) Place a thin, skin-tight coating of a plasticlike material over the compressed tablet Having essentially the same weight, shape and size as the originally compressed tablet The coating is thin enough to reveal any identifying compression by the tablet punches Far more resistant to destruction by abrasion than are sugarcoated tablets.
4. Describe the factors influencing the mixing process.( In English) (5 分) Components ratio Density Cohesion and charge Containing liquid or hygroscopic components Adsorbents Hygroscopic components Containing crystal water: use anhydrous substitute Highly hygroscopic: operate under CRH Hydroscopic after mixing: Packed individually Containing eutectic mixtures
板凳
beyond 发表于 11-7-30 20:26:13 | 只看该作者
地板
beyond 发表于 11-7-30 20:26:42 | 只看该作者
沈阳药科大学药物化学2009期末试题集
http://wenku.baidu.com/view/f519549851e79b8968022674.html
5#
beyond 发表于 11-7-30 20:27:10 | 只看该作者
沈阳药科大学生化期末考试题3
http://wenku.baidu.com/view/767405dc5022aaea998f0fc1.html
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